1. Identification
2. Composition/Information on Ingredients
3. Hazards Identification
4. First Aid Measures
5. Fire Fighting Measures
6. Accidental Release Measures
7. Handling and Storage
8. Exposure Control/Personal Protection
9. Physical and Chemical Properties
10. Stability and Reactivity
11. Toxicological Information
12. Ecological Information
13. Disposal Consideration
14. Transport
15. Regulatory Information
16. Other Information

Preparation:

Supplier:

Nomix Enviro Ltd, Portland Building, Portland Street, Staple Hill, Bristol BS16 4PS
T: 0117 957 4574; F: 0117 956 3461

Active Ingredient
Potassium salt of N-(phosphonomethyl)glycine; {potassium salt of glyphosate}

Composition:

MAPP Number:

National Classification - UK
R52/53: Harmful to aquatic organisms, may cause long-term adverse effects in the environment

Potential Health Effects
Likely routes of exposure
Skin contact, eye contact, inhalation
Eye contact, short term
Not expected to produce significant adverse effects when recommended use instructions are followed.
Skin contact, short term
Not expected to produce significant adverse effects when recommended use instructions are followed.
Inhalation, short term
Not expected to produce significant adverse effects when recommended use instructions are followed.

Potential Environmental Effects
Harmful to aquatic organisms
May cause long-term adverse effects in the aquatic environment

Refer to section 11 for toxicological and section 12 for environmental information.

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Eye Contact
Immediately rinse with plenty of water.
If easy to do, remove contact lenses.
If there are persistent symptoms, obtain medical advice.

Skin Contact
Wash affected skin with plenty of water.
Take off contaminated clothing, wristwatch, jewellery.
Wash clothes and clean shoes before re-use.
If there are persistent symptoms, obtain medical advice.

Inhalation
Remove to fresh air.

Advice to Doctors
This product is not an inhibitor of cholinesterase.

Antidote
Treat with atropine and oximes is not indicated.

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Extinguishing media
Recommended: Water, foam, dry chemical, carbon dioxide (CO2)

Unusual fire and explosion hazards
Minimise use of water to prevent environmental contamination.
Environmental precautions: see section 6.

Hazardous products of combustion
Carbon monoxide (CO), phosphorous oxides (PxOy), nitrogen oxides (NOx)

Fire fighting equipment
Self-contained breathing apparatus.
Equipment should be thoroughly decontaminated after use.

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Environmental precautions
Minimise spread.
Keep out of drains, sewers, ditches and waterways.
Notify authorities.

Methods of cleaning up
Absorb in earth, sand or absorbent material.
Dig up heavily contaminated soil.
Rrefer to section 10 for types of containers.
Collect in containers for disposal.
Flush residues with small quantities of water.
Minimise use of water to prevent environmental contamination.

Refer to section 13 for disposal of spilled material.

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Handling
Avoid contact with eyes.
When using do not eat, drink or smoke.
Wash hands thoroughly after handling or contact.
Wash contaminated clothing before re-use.
Thoroughly clean equipment after use.
Do not contaminate drains, sewers and water ways when disposing of equipment rinse water.
Refer to section 13 for disposal of rinse water.
Emptied containers retain vapour and product residue.
FOLLOW LABELLED WARNINGS EVEN AFTER CONTAINER IS EMPTIED.

Storage
Minimum storage - 15°C.
Maximum storage - 50°C
Compatible materials for storage: stainless steel, aluminium, fibreglass, plastic, glass lining.
Incompatible materials for storage: galvanised steel, unlined mild steel, see section 10.
Keep out of reach of children.
Keep away from food, drink and animal feed.
Keep container tightly closed in a cool, well ventilated place.
Keep only in the original container.
Minimum shelf life: 2 years.

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Engineering controls
No special requirement when used as recommended.

Eye protection
If there is significant potential for contact:
Wear chemical goggles.

Skin protection
If repeated or prolonged contact:
Wear chemical resistant gloves.

Respiratory protection
No special requirement when used as recommended.

When recommended, consult manufacturer of personal protective equipment for the appropriate type of equipment for a given application.

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Colour/colour range: yellow - amber
Form: liquid
Odour: slight, amines
Flash point: does not flash
Kinematic viscosity: 13.81 cSt @ 20°C
Density: 1.308 g/cm3 @ 20°C
pH: 4.5 - 5.5 @ 10 g/l
Partition coefficient (log Pow): -3.2 @ 25°C (glyphosate)

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Hazardous Decomposition
Thermal decomposition: Hazardous products of combustion: see section 5.

Materials to avoid/Reactivity
Reacts with galvanised steel or unlined mild steel to produce hydrogen, a highly flammable gas that could explode.

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Data obtained on similar products and on components are summarised below.

More concentrated formulation

Skin sensitisation
Guinea pig, modified Buehler test:
Negative

More concentrated formulation

Acute oral toxicity
Rat, LD50 (limit test): >5,000 mg/kg body weight
Target organs/systems: none
No mortality

Acute dermal toxicity
Rat, LD50 (limit test): >5,000 mg/kg body weight
Target organs/systems: none
No mortality

Skin Irritation
Rabbit, 6 animals, OECD 404 test:
Redness, mean EU score: 0.5
Swelling, mean EU score: 0.0
Days to heal: 3

Eye Irritation
Rabbit, 6 animals, OECD 405 test:
Conjunctival redness, mean EU score: 1.83
Conjunctival swelling, mean EU score: 1.44
Corneal opacity, mean EU score: 1.33
Iris lesions, mean EU score: 0.89
Days to heal: 14
Slightly irritating to eyes but not sufficient for classification.

N-(phosphonomethyl)glycine {glyphosate}

Mutagenicity
In vitro and in vivo mutagenicity test(s):
Not mutagenic.
Repeated dose toxicity
Rabbit, dermal, 21 days
NOAEL toxicity:>5,000 mg/kg body weight/day
Target organs/systems: none
Other effects: none
Rat, oral, 3 months:
NOAEL toxicity:> 20,000 mg/kg diet
Target organs/systems: none
Other effects: none
Chronic effects/carcinogenicity
Mouse, oral, 24 months:
NOEL tumour:>30,000 mg/kg diet
NOAEL toxicity: ~ 5,000 mg/kg diet
Tumours: none
Target organs/systems: liver
Other effects: decrease of body weight gain, histopathologic effects.
Rat, oral, 24 months:
NOEL tumour:>20,000 mg/kg diet
NOAEL toxicity: ~ 8,000 mg/kg diet
Tumours: none
Target organs/systems: eyes
Other effects: decrease of body weight gain, histopathologic effects.
Toxicity to reproduction/fertility
Rat, oral, 2 generations
NOAEL toxicity: ~ 10,000 mg/kg diet
NOAEL reproduction:>30,000 mg/kg diet
Target organs/systems in parent: none
Other effects in parents: decrease of body weight gain
Target organs/systems in pups: none
Other effects in pups: decrease of body weight gain
Effects on offspring only observed with maternal toxicity.
Developmental toxicity/teratogenicity
Rat, oral, 6 - 19 days of gestation:
NOAEL toxicity: 1,000 mg/kg body weight
NOAEL development: 1,000 mg/kg body weight
Other effects in mother animal: decrease of body weight gain, decrease of survival
Developmental effects: weight loss, post-implantation loss, delayed ossification
Effects on offspring only observed with maternal toxicity.
Rabbit, oral, 6 - 27 days of gestation:
NOAEL toxicity: 175 mg/kg body weight
NOAEL development: 175 mg/kg body weight
Target organs/systems in mother animal: none
Other effects in mother animal: decrease of survival
Developmental effects: none

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Data obtained on similar products and on components are summarised below.

Similar formualtion

Aquatic toxicity, algae/aquatic plants
Green algae (Selenastrum capricornutum):
Acute toxicity, 72 hours, static, ErC50 (growth rate): 14mg/L
Arthropod Toxicity
Honey bee (Apis mellifera):
Contact, 48 hours, LD50:>265 µg/bee
Honey bee (Apis mellifera):
Oral, 48 hours, LD50:>285 µg/bee
Soil organism toxicity, invertebrates
Earthworm (Eisenia foetida)
Acute toxicity, 14 days, LC50:>2,700 mg/kg dry soil
Soil organism toxicity, microorganisms
Nitrogen and carbon transformation test:
48 L/ha, 28 days: Less than 25% effect on nitrogen or carbon transformation processes in soil.

Similar formualtion

Aquatic toxicity, fish
Rainbow trout (Oncorhynchus mykiss):
Acute toxicity, 96 hours, static, LC50: 18 mg/L
Aquatic toxicity, invertebrates
Water flea (Daphnia magna):
Acute toxicity, 48 hours, static, EC50: 52 mg/L
Avian toxicity
Bobwhite quail (Colinus virginianus):
Acute oral toxicity, single dose, LD50:> 2,250 mg/kg body weight

N-(phosphonomethyl)glycine; {glyphosate}

Avian toxicity
Bobwhite quail (Colinus virginianus):
Dietary toxicity, 5 days, LC50:> 4,640 mg/kg diet
Mallard Duck (Anas platyrhynchos)
Dietary toxicity, 5 days, LC50:> 4,640 mg/kg diet
Bobwhite quail (Colinus virginianus):
Acute oral toxicity, single dose, LD50:> 3,851 mg/kg body weight
Bioaccumulation
Bluegill sunfish (Lepomis macrochirus):
Whole fish: BCF: < 1
No significant bioaccumulation is expected.
Dissipation
Soil, field:
Half life: 2 - 174 days
Koc: 884 - 60,000 L/kg
Adsorbs strongly to soil.
Water, aerobic:
Half life: < 7 days

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Container
See the individual container label for disposal information.
Emptied containers retain vapour and product residue.
Observe all labelled safeguards until container is cleaned, reconditioned or destroyed.
Empty packaging completely.
Triple or pressure rinse empty containers.
Do NOT contaminate water when disposing of rinse waters.
Dispose of rinse waters as hazardous waste.
Ensure packaging cannot be reused.
Follow all local/regional/national/international regulations.

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Not regulated for transport.

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R52/53: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

National classification - UK
R52/53: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
S2: Keep out of reach of children.
S13: Keep away from food, drink and animal feeding stuffs.

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Endnotes:
{a} EU label (manufacturer self-classification)
{b} EU label (Annex I)
{c} National classification

Full denomination of most frequently used acronyms. BCF (Bioconcentration Factor), BOD (Biochemical Oxygen Demand), COD (Chemical Oxygen Demand), EC50 (50% effect concentration), ED50 (50% effect dose), I.M. (intramuscular), I.P. (intraperitoneal), I.V. (intravenous), Koc (Soil adsorption coefficient), LC50 (50% lethality concentration), LD50 (50% lethality dose), LDLo (Lower limit of lethal dosage), LEL (Lower Explosion Limit), LOAEC (Lowest Observed Adverse Effect Concentration), LOAEL (Lowest Observed Adverse Effect Level), MEL (Maximum Exposure Limit), MTD (Maximum Tolerated Dose), NOAEC (No Observed Adverse Effect Concentration), NOAEL (No Observed Adverse Effect Level), NOEC (No Observed Effect Concentration, NOEL (No Observed Effect Level), OEL (Occupational Exposure Limit), PEL (Permissable Exposure Limit), PII (Primary Irritation Index, Pow (Partition coeffecient, n-octanol/water), S.C. (subcutaneous), STEL (Short-Term Exposure Limit), TLV-C (Threshold Limit Value-Ceiling), TLV-TWA (Threshold Limit Value - Time Weighted Average), UEL (Upper Explosion Limit).

Although the information and recommendations set forth herein (hereinafter "Information") are presented in good faith and believed to be correct as of the date hereof, Nomix Enviro makes no representations as to the completeness or accuracy thereof. Information is supplied upon the condition that the persons receiving same will make their own determination as to its suitability for the purposes prior to use. In no event will Nomix Enviro be responsible for damages of any nature whatsoever resulting from the use or reliance upon information. NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, OF MERCHANTIBILITY, FITNESS FOR A PARTICULAR PURPOSE OR OF ANY OTHER NATURE ARE MADE HEREUNDER WITH RESPECT TO INFORMATION OR TO THE PRODUCT TO WHICH INFORMATION REFERS.

Date of MSDS Review: 24/03/06

Supersedes MSDS Dated: N/A    

© Nomix Enviro Limited 2006.

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